Daflon 500 — original French venotonic, strengthens vein walls, relieves hemorrhoids and varicose veins
💊 Active ingredient: Diosmin + Hesperidin (MPFF) ⏱️ How to use: Follow the acute or chronic dosing protocol 🍽️ Condition: Take with food 📦 Pack: 30 tablets (2 blister strips of 15) ⚡ Highlight: Original brand used in over 90 countries 🌡️ Storage: Below 30°C, away from sunlight and moisture
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Product Description
Daflon 500 contains MPFF (Micronized Purified Flavonoid Fraction): Diosmin 450 mg and Hesperidin 50 mg. It strengthens vein walls, reduces capillary permeability, and improves lymphatic drainage, relieving both acute and chronic hemorrhoids as well as varicose veins of the legs.
📊 Key facts about hemorrhoids:
A Korean national survey found 14.4% prevalence of hemorrhoids, slightly more common in women (Korean NHANES)
Chronic constipation raises hemorrhoid risk 4.32-fold, and BMI ≥25 raises it 2.6-fold compared to the general population
Double-blind clinical trials confirm MPFF reduces bleeding and pain in acute hemorrhoids
🏭 Manufactured by Les Laboratoires Servier, a leading French pharmaceutical company, and sold in over 90 countries worldwide.
⚠️ If symptoms do not improve after completing the treatment protocol, consult a doctor or pharmacist for further evaluation.
Can be combined with a topical hemorrhoid treatment such as Doproct Ointment for relief both internally and externally.
Medically reviewed by
Supatcheree A., Pharmacist | Sources: PubMed, PMC, Nature
Last reviewed: 2026-07-03
About Daflon
What Is Daflon?
Daflon 500 is manufactured by Les Laboratoires Servier, France. Its active ingredient is MPFF (Micronized Purified Flavonoid Fraction), containing Diosmin 450 mg (90%) and Hesperidin 50 mg (10%), derived from citrus plants.
Mechanism: MPFF improves the elasticity and strength of vein walls, reduces capillary permeability, enhances lymphatic drainage, and reduces inflammation in the venous system. This improves circulation in the anal area, reducing swelling, bleeding, and pain.
Daflon belongs to the phlebotonic drug class, working systemically through the circulatory system rather than providing only local relief like topical creams or suppositories.
Daflon is the original branded formulation of MPFF, used for decades and among the most clinically studied oral medicines for venous disease worldwide.
What Does Daflon Treat?
Daflon is used to relieve symptoms arising from venous insufficiency, including:
Hemorrhoids — internal, external, and mixed types; reduces bleeding, pain, swelling, and itching
Acute hemorrhoidal episodes — sudden severe flare-ups with bleeding or inflammation
Chronic hemorrhoids — reduces frequency and severity of recurrence, from Grade 1 (not prolapsed) through Grade 2-3
Varicose veins and chronic venous insufficiency (CVI) — heavy legs, swelling, pain, heat sensation
Daflon treats both hemorrhoids and varicose veins together since both share the same root cause: weakened vein walls. Doctors often recommend it for patients experiencing both conditions at once.
How to Take Daflon and Dosage
Daflon has different dosage protocols depending on the condition. Swallow tablets whole with food, do not chew or crush them:
Acute hemorrhoids:
First 4 days: 6 tablets/day — 3 in the morning and 3 in the evening with meals
Next 3 days: 4 tablets/day — 2 in the morning and 2 in the evening with meals
Chronic hemorrhoids / varicose veins:
2 tablets/day with dinner, or 1 tablet morning and 1 evening, for 60-90 days
1000 mg strength: Take 1 tablet once daily for chronic/maintenance therapy, delivering the same total dose as 500 mg twice daily — designed for once-daily convenience. Always follow the label or your pharmacist's advice.
If a dose is missed, skip it and take the next dose as usual — never double dose. Take it at the same time each day to keep a steady blood level. Store below 30°C, away from sunlight and moisture.
Side Effects of Daflon
Daflon has an excellent safety profile, with clinical trials showing side effects comparable to placebo. The following may occasionally occur:
Gastrointestinal (most common):
Abdominal pain, bloating, or diarrhea — especially early in treatment
Nausea, vomiting, belching, indigestion
Less common:
Headache, dizziness, rash, itching
Very rare:
Hives or skin allergic reactions
These usually resolve as the body adjusts. Always take Daflon with food to reduce stomach irritation. If a severe allergic reaction occurs (facial swelling, difficulty breathing), stop use and seek medical attention immediately.
Contraindications and Precautions for Daflon
Contraindications: Allergy to Diosmin, Hesperidin, or any component of Daflon
Consult a doctor or pharmacist before use if you are:
Pregnant or breastfeeding — limited safety data available
A child — not recommended; insufficient safety data
Living with severe liver or kidney disease
Precautions: If symptoms or bleeding do not improve after completing the protocol, seek medical evaluation to rule out other serious conditions such as colorectal cancer. Daflon is not a painkiller or antibiotic — it treats vascular insufficiency only. Grade 3-4 hemorrhoids that prolapse and cannot be manually reduced usually require an additional procedure or surgery.
Daflon Compared With Other Hemorrhoid Medicines
Oral hemorrhoid medicines available at Intimo Life:
Quick guide: Want a clinically tested protocol with international trial data → Daflon / Prefer a natural Thai herbal option at a lower cost → Phet Sangkhat (Cissus quadrangularis)
Can Daflon Be Used With Other Medicines?
Daflon has very few drug interactions since it is a plant-derived flavonoid, not a synthetic drug. However, inform your doctor or pharmacist if you are using:
Anticoagulants such as Warfarin — monitor blood clotting closely
Antiplatelet drugs such as Aspirin — usable together but inform your provider
Herbal supplements affecting blood vessels — disclose these as well
Daflon can be safely combined with Doproct Suppository since they treat two different levels — internal and external. Consult a pharmacist if uncertain about your current medications.
How Fast Does Daflon Work?
Daflon works faster than many expect, especially for acute hemorrhoids:
Days 2-3: Bleeding, pain, and discomfort noticeably improve
Days 4-7: Continued improvement; hemorrhoids shrink
For varicose veins / leg swelling — benefits become clear over 2-4 weeks
For best results, combine with a high-fiber diet, adequate hydration, avoiding straining, and warm sitz baths. Chronic hemorrhoids may need 2-3 months of continuous use for lasting long-term results.
Where to Buy Daflon?
Where to Buy Daflon?
Order Daflon online at Intimo Life with delivery throughout Thailand in 1-3 business days. All orders are packed discreetly with no product name indicated on the outer packaging.
⚠️ Disclaimer
The content in this article is for general educational purposes only. It is not intended to replace professional advice, diagnosis, or treatment from a doctor or pharmacist. If you have any questions about symptoms or medication use, always consult a doctor or pharmacist first.
Hemorrhoids develop when veins around the anus become swollen. Main causes include chronic constipation or frequent straining, excess weight, prolonged sitting, pregnancy, heavy lifting, and genetics. The best prevention is treating constipation and staying well-hydrated.
Avoid foods that cause constipation or irritate the rectum, such as low-fiber processed foods, fried and fatty foods, spicy foods, alcohol, and excessive coffee. Add more vegetables and fruit and drink at least 8 glasses of water daily to keep stools soft and easy to pass.
Always take Daflon with food to reduce stomach irritation and improve absorption. Taking it on an empty stomach may cause nausea or bloating, especially during the acute protocol of 6 tablets per day.
Daflon relieves symptoms and strengthens vein walls, but it does not permanently cure hemorrhoids if the underlying causes, such as constipation or excess weight, are not addressed. Hemorrhoids can return. For permanent removal, a procedure or surgery may be needed.
Safety data for Daflon during pregnancy is limited, so always consult a doctor or pharmacist before use. During pregnancy, lifestyle changes such as more fiber and fluids, or a doctor-recommended topical treatment, may be suggested instead.
Always check the expiry date (EXP) printed on the box and blister strip before use. Daflon generally has a shelf life of several years from manufacture if stored correctly — below 30°C, away from sunlight and moisture. Never use expired medicine.
Hemorrhoid bleeding is typically bright red and occurs during bowel movements. If other warning signs are present, such as age over 50, unexplained weight loss, or a change in bowel habits, see a doctor to rule out more serious conditions.
Stand up and change position every 30-60 minutes, avoid straining or lingering on the toilet, increase daily fiber and water intake, and exercise regularly to reduce pressure in the lower veins.
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