Domperidone
Motilium
Motilium (Domperidone) — antiemetic tablet, stimulates gastric motility, relieves nausea
💊 Active ingredient: Domperidone
⏱️ Directions: Take 30 min before meals, 3x daily
🍽️ Condition: Always take before meals for best absorption
📦 Pack: 10 tablets per strip, film-coated
⚡ Key benefit: Fast nausea relief, non-drowsy
🌡️ Storage: Room temp below 30°C, away from sunlight
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What is Motilium (Domperidone)?
Motilium (Domperidone) is a prokinetic antiemetic that stimulates gastric contractions so food moves through the stomach faster, while blocking dopamine receptors at the brain's vomiting control center. It relieves nausea, vomiting, bloating, and indigestion caused by slow stomach emptying. Unlike antidiarrheals or antacids, it works directly on gut motility rather than acid or stool consistency.
🛒 10 tablets/strip · authentic · 24-hour dispatch from Intimo Life — consult a doctor or pharmacist before use.
Product Description
Antiemetic medicine Motilium contains Domperidone, a prokinetic that helps the stomach contract more effectively, moving food through faster. It also blocks dopamine receptors at the brain's vomiting center (CTZ), which sits largely outside the blood-brain barrier, reducing nausea, vomiting, bloating, and indigestion. It suits people with slow stomach emptying (gastroparesis) or fullness after meals.
📊 Key facts about Domperidone
- Onset is roughly 30-60 minutes after a dose, with a half-life of about 7-9 hours
- It crosses into the brain far less than some other antiemetics, so neurological side effects are less common
- UK's MHRA advises the lowest effective dose for the shortest time, especially in older adults
- For acute diarrhea unrelated to slow stomach emptying, a more targeted option is Imodium (Loperamide)
🏭 Motilium is manufactured by Johnson & Johnson, legally imported and distributed in Thailand
⚠️ Extra caution is needed in older adults or higher doses, as it may affect heart rhythm (QT prolongation) — consult a pharmacist before use
About Motilium (Domperidone)
What is Motilium (Domperidone)?
Motilium (Domperidone) is a prokinetic and dopamine antagonist antiemetic. Its active ingredient, Domperidone, stimulates the stomach and upper small intestine to contract, moving food through the digestive tract faster. It also blocks dopamine receptors at the brain's chemoreceptor trigger zone (CTZ), which sits mostly outside the blood-brain barrier, so it affects the central nervous system less than some other antiemetics that act directly through the brain.
Domperidone's key strength as an antiemetic is its dual action: it speeds up stomach movement while also reducing the nausea signal from the brain at the same time, addressing both the cause and the sensation together. Motilium comes as 10 mg film-coated tablets, packed 10 tablets per strip, meant to be taken around mealtimes every day, based on a pharmacist's advice.
What does Domperidone treat?
Domperidone relieves symptoms linked to abnormal stomach movement and nausea from several causes:
- Nausea and vomiting — from indigestion, slow stomach emptying, or side effects of certain medicines
- Bloating and indigestion (dyspepsia) — feeling full quickly or bloated after meals, often alongside chronic nausea
- Gastroparesis — food staying in the stomach longer than normal, causing repeated fullness and nausea
- In some cases, doctors prescribe it alongside other treatments to reduce nausea caused by Parkinson's disease medicines or certain chemotherapy drugs
Domperidone is not a direct treatment for diarrhea or acid reflux — it targets the underlying cause of nausea from slow stomach movement instead, making it a suitable oral antiemetic choice distinct from antacids or antidiarrheals.
How to take Domperidone / Dosage
Take Motilium (Domperidone 10 mg) 30 minutes before meals, three times daily. Swallow the tablet whole with a full glass of water. Taking it before meals allows this antiemetic to start stimulating the stomach in time, before food enters the digestive tract.
Dose and duration depend on your doctor's or pharmacist's judgment. It's generally recommended to use the lowest effective dose for the shortest necessary period — avoid continuous use longer than advised, especially in older adults. If nausea and vomiting don't improve or get worse, see a doctor to investigate further.
Caution: Never increase the dose on your own even if symptoms haven't improved, as a higher dose raises the risk of heart-related side effects. Consult a pharmacist if symptoms don't improve within a week, or if you need to keep taking it longer than that.
Side effects of Domperidone
Common, usually mild side effects:
- Dry mouth, mild headache
- Occasional diarrhea or stomach pain
- Breast tenderness or unusual milk discharge (from raised prolactin) — uncommon
⚠️ Serious side effects requiring immediate discontinuation: Domperidone carries a risk of abnormal heart rhythm (QT prolongation) and, in rare cases, serious arrhythmia — especially in older adults or those on higher doses. If you experience palpitations, dizziness, fainting, or an unusually fast heartbeat, stop the medicine and see a doctor immediately.
Contraindications / Precautions
Avoid or consult a doctor before using this antiemetic in these cases:
- Heart disease, arrhythmia, or a pre-existing prolonged QT interval
- Moderate to severe liver impairment, which may slow how the body clears the drug
- A pituitary tumor that raises prolactin levels (prolactinoma)
- Gastrointestinal bleeding, bowel obstruction, or a perforated gut, where added stomach contraction is not advisable
- Taking certain medicines that affect heart rhythm or inhibit the CYP3A4 enzyme
Always tell your pharmacist or doctor about any existing conditions or other medicines you take before starting Domperidone, so they can assess suitability and safety.
Can Domperidone be taken with other medicines?
Domperidone interacts with a few classes of medicine that need special caution:
- Certain antifungals or antibiotics that inhibit CYP3A4 (e.g., ketoconazole, erythromycin) — raise Domperidone blood levels and increase arrhythmia risk
- Other QT-prolonging medicines — should not be combined, as this significantly raises risk
- Antacids or acid-reducing medicines — may lower Domperidone absorption if taken together; space doses apart
Always tell your pharmacist or doctor what medicines you're taking before starting Domperidone, for safety.
How fast does Domperidone work?
Domperidone acts fairly quickly compared with some other digestive medicines — relief from nausea and improved stomach contraction typically begins within about 30-60 minutes after taking it, and its effect lasts around 7-9 hours based on the drug's half-life before blood levels gradually decline.
That's why it's recommended to take it 30 minutes before meals, so the drug is already working to stimulate the stomach right as food enters the digestive tract. Taking it after a meal may reduce how well it relieves symptoms, since food arrives before the drug has fully kicked in.
Where to buy Motilium?
Where to buy Motilium?
Order Motilium (Domperidone) online at Intimo Life with nationwide delivery across Thailand in 1-3 business days, packed discreetly with no product name shown on the parcel.
⚠️ Disclaimer
The content in this article is for general educational purposes only. It is not intended to replace professional advice, diagnosis, or treatment from a doctor or pharmacist. If you have any questions about symptoms or medication use, always consult a doctor or pharmacist first.
References
Frequently Asked Questions
Taking it 30 minutes before a meal works best, since the drug needs time to start stimulating the stomach before food arrives in the digestive tract. Taking it with or right after a meal means it kicks in later than when the stomach needs the most help, which can reduce how well it relieves nausea.
Most people start feeling less nauseated within 30-60 minutes of taking the tablet. Once symptoms ease, you can resume your next meal as usual, though it's best to start with small, easy-to-digest portions. If nausea or vomiting continues for more than 2-3 days, see a doctor.
Domperidone isn't a primary treatment for motion sickness, since it mainly acts on stomach movement and the digestive-related vomiting center rather than the inner-ear balance center that causes travel sickness. Medicines made specifically for motion sickness work better for this. If unsure, ask a pharmacist.
Always consult a doctor first, as safety data for this medicine in pregnancy is limited. A doctor will weigh the necessity of treatment against potential risks and may suggest a more suitable alternative in certain cases.
Paracetamol can generally be taken with Domperidone without a major interaction. Antacids, however, should be spaced at least 1-2 hours apart from your dose, since some antacids can reduce Domperidone absorption. If unsure, ask a pharmacist before combining them.
It can only be used under a doctor's judgment, with dosing adjusted by body weight. Don't give it to a child on your own for general symptoms without medical advice, as children face a higher risk of heart-related and neurological side effects than adults.
If it's not yet close to your next meal, take it as soon as you remember. If it's nearly time for the next dose, skip the missed one and continue your normal schedule. Never double up to make up for a missed dose, as this raises the risk of heart-related side effects.
Tablets still sealed in the foil strip keep until the expiry date printed on the box, as long as they're stored in a dry place at room temperature, away from direct sunlight. Once a tablet is popped out of the strip, use it as soon as possible and keep it away from moisture to preserve effectiveness.
A full box of Motilium contains 30 tablets (3 strips). Selling it by the 10-tablet strip lets customers buy just the amount they actually need, avoiding overpaying for a short-term course, while the tablets stay sealed in the foil strip until opened.
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