Flunarizine

Sobelin

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Sobelin — a nightly migraine-prevention capsule that reduces attack frequency and severity

💊 Active ingredient: Flunarizine, a calcium-channel blocker
⏱️ How to use: Take 1 capsule nightly, continuously
🍽️ Timing: With or without food
📦 Pack: 10-capsule strip or 500-capsule box
⚡ Highlight: Prevents migraine long-term, not for acute pain
🌡️ Storage: Below 30°C, away from sunlight

Option: 10-Capsule Strip
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Discreet shipping within Thailand — packaging does not identify the product. Customers can review shipping and return conditions per our store policy. Contact our team for any questions.

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What Is Sobelin?

Sobelin is a migraine-prevention medicine containing Flunarizine 5 mg per capsule, a calcium-channel blocker that reduces how often and how severely migraines occur when taken daily. It is not an acute pain medicine taken during an attack. Adults take it at night, and it typically needs 8-12 weeks of continuous use to show a clear effect.

🛒 Available as a 10-capsule strip or a 500-capsule box · Genuine · 24-hour dispatch from Intimo Life — consult a doctor or pharmacist before use.

Product Description

Migraine-prevention medicine Sobelin contains Flunarizine as its active ingredient, a calcium-channel blocker manufactured by T.O. Chemicals. It is used to prevent migraine in people with frequent, severe headaches — unlike acute migraine treatments such as Sumigran or Tofago that are taken during an attack, Sobelin must be taken continuously every night to reduce how often migraines occur over time.

📊 Key statistics:

  • Clinical studies show Flunarizine significantly reduces migraine frequency compared with placebo, with a clear effect after 8-12 weeks of continuous use
  • Drowsiness affects up to around 40% of users during the first month, usually improving as the body adjusts
  • Depression is the leading reason for stopping treatment, affecting around 1-7% of migraine patients using this drug class

🏭 Manufactured by T.O. Chemicals (1979), imported and distributed in Thailand under registration no. 1A 262/31

⚠️ Not for use in people with a history of depression or Parkinson's disease; consult a pharmacist before use in elderly patients

Supatcheree A., Pharmacist

Medically reviewed by

Supatcheree A., Pharmacist | Sources: MIMS, NDI, NICE, GOSH NHS

Last reviewed: 2026-07-20

About Sobelin

What Is Sobelin?

Sobelin is a migraine-prevention medicine containing Flunarizine hydrochloride 5 mg per capsule, manufactured by T.O. Chemicals (1979) Ltd. and registered under Thai FDA number 1A 262/31. Flunarizine is a calcium-channel blocker that works by reducing constriction of blood vessels in the brain and lowering sensitivity to migraine triggers. It is used as a preventive treatment for people with frequent, severe migraines, rather than a medicine taken to relieve pain during an active attack like acute migraine treatments. It must be taken continuously every day as directed by a doctor to reduce how often migraine attacks occur.

What Is Sobelin Used For?

Sobelin's main indication is migraine prevention for people with frequent or severe migraine headaches, especially those not well controlled by standard pain relievers. Flunarizine is also labeled for relieving vertigo from balance-system disorders and certain cerebral and peripheral circulatory conditions. In practice, most customers at this store use Sobelin specifically for migraine prevention, not for other headache types such as tension headaches or sinus headaches.

How to Take Sobelin / Dosage

Sobelin is usually taken at night, since dosing before bed reduces how much the drowsiness side effect interferes with daily life. The typical adult dose for those under 65 starts at 2 capsules (10 mg) at night, while adults 65 and older start at 1 capsule (5 mg) at night. A doctor may adjust the dose based on individual response and side effects. It needs to be taken continuously for at least 8-12 weeks before its effect can be properly assessed. If symptoms improve, some doctors recommend a 2-day break each week (such as Saturday and Sunday) to reduce drug accumulation in the body. Do not adjust the dose or stop the medicine on your own without consulting a doctor or pharmacist.

Side Effects of Sobelin

The most common side effect of Sobelin is drowsiness, affecting many users especially during the first month, which usually improves as the body adjusts. The next most common effect is weight gain from increased appetite. The side effect that needs the closest attention is depression, which is the leading reason people stop taking this medicine — report symptoms such as low mood, loss of interest in usual activities, or major changes in sleep to a doctor immediately. Elderly patients face a higher risk of Parkinson's-like symptoms (extrapyramidal symptoms) such as hand tremor or slowed movement, which usually improve after stopping the drug, so this age group should use it under close medical supervision.

Contraindications / Precautions

Do not use Sobelin if you have a history of depression, Parkinson's disease or Parkinson's-like symptoms, or an allergy to Flunarizine or its ingredients. Pregnant women should avoid this medicine unless a doctor determines the benefits outweigh the risks, and breastfeeding mothers should not nurse while taking it. Elderly patients should use it with extra caution due to a higher risk of drowsiness and Parkinson's-like symptoms. Anyone who drives or operates machinery should be cautious of drowsiness, especially early in treatment, and alcohol should be avoided since it intensifies the drug's central nervous system depressant effect.

How Does Sobelin Compare to Other Migraine Medicines?

Within the same Flunarizine class of migraine-prevention medicine, this store also carries Flurin, another brand using the same active ingredient and mechanism as Sobelin, differing mainly in manufacturer and packaging. Sumigran (Sumatriptan) and Tofago (Ergotamine Tartrate) are a different drug class used to relieve an active migraine attack, not to prevent one, so they serve an entirely different purpose and timing than Sobelin. Some doctors prescribe Sobelin alongside an acute rescue medicine so patients get both fewer long-term attacks and relief during a flare-up. In short: choose Sobelin or Flurin for daily migraine prevention taken ahead of time, and choose Sumigran or Tofago only to relieve pain once a migraine attack has already started.

Can Sobelin Be Taken With Other Medications?

Sobelin's central nervous system depressant effect is intensified when combined with other sedating medicines, such as sedating antihistamines, sleep aids, anti-anxiety medicines, or alcohol, causing more drowsiness than usual — avoid combining or consult a pharmacist first. Do not combine with monoamine oxidase inhibitors (MAOIs), as this risks a severe reaction affecting the nervous system and blood pressure. Acute migraine medicines such as Sumigran or Tofago can be used alongside Sobelin under a doctor's guidance, since they work through different mechanisms for different purposes. Always tell your pharmacist about all medicines you are currently taking before starting Sobelin.

How Fast Does Sobelin Work?

Sobelin does not work instantly like an acute migraine medicine. It needs to be taken continuously every day for at least 8-12 weeks before a clear reduction in migraine frequency and severity shows up. Some people notice mild improvement as early as weeks 4-6, but the medicine needs the full evaluation period before judging its effect. If there is no improvement at all after 2 months, go back to a doctor to consider adjusting the dose or switching to a different migraine-prevention approach. Do not stop the medicine on your own just because you do not see results in the first week or two.

Where Can I Buy Sobelin?

Where Can I Buy Sobelin?

Order Sobelin online at Intimo Life with nationwide delivery across Thailand in 1-3 business days. Packaging is discreet and does not identify the product on the parcel.

⚠️ Disclaimer

The content in this article is for general educational purposes only. It is not intended to replace professional advice, diagnosis, or treatment from a doctor or pharmacist. If you have any questions about symptoms or medication use, always consult a doctor or pharmacist first.

Frequently Asked Questions

Flunarizine 5 mg is the name and strength of the active ingredient contained in Sobelin, not a separate medicine. Sobelin is the brand name, while Flunarizine is the generic name, similar to how paracetamol has multiple brand names on the market. Flunarizine 5 mg is also sold under other brands, such as Flurin, which uses the same active ingredient and strength.

Take it mainly at night. It can be taken with or without food, since it does not significantly irritate the stomach. Dosing at night reduces how much the drowsiness side effect disrupts daily activities. Take it at the same time every night to keep blood levels steady, and continue as prescribed even if you do not notice improvement right away.

The most common side effects are drowsiness and weight gain. The one requiring special attention is depression, especially in elderly patients who carry a higher risk. Tell your doctor immediately if you notice low mood, loss of interest in things you used to enjoy, or thoughts of not wanting to live — the medicine may need to be stopped.

Yes. Multiple clinical studies confirm that Flunarizine significantly reduces migraine frequency compared with placebo, particularly in people with 2 or more migraines per month. However, it must be taken continuously for at least 8-12 weeks before a clear effect appears — it does not work instantly.

Weight gain is a common side effect linked to increased appetite, though severity varies by individual. If weight increases quickly or excessively, consult a doctor, who may adjust the dose or suggest dietary changes. Do not stop the medicine on your own out of concern about weight.

If you remember the next morning, skip the missed dose and take the next one at the usual time that night. Never double the dose to make up for a missed one, as this only raises the risk of side effects unnecessarily. Missing one night has little impact since the medicine takes several weeks to build up its effect.

Not recommended. Pregnant women should avoid Sobelin unless a doctor determines the benefits outweigh the risks, since there is not enough safety data for this group. Breastfeeding mothers should not nurse while using it. Always consult a doctor before taking Sobelin if you are pregnant, planning a pregnancy, or breastfeeding.

If there is no improvement at all after 2 months of continuous use, go back to a doctor for reassessment. They may adjust the dose, switch to a different migraine-prevention medicine, or reconsider whether the headaches are actually migraines. Do not increase the dose yourself or stop abruptly without consulting a doctor.

Store at room temperature below 30°C, away from direct sunlight and moisture, in its original sealed container. Avoid popping capsules out of the blister strip too far in advance, and always keep out of reach of children. Shelf life is typically 36 months from the manufacture date — always check the expiry date on the packaging before use.

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