Dermovate Cream (เดอร์โมเวท) Clobetasol Topical Steroid 5g

Dermovate Cream is a super-potent topical corticosteroid (Class I) containing Clobetasol propionate 0.05%, manufactured by GlaxoSmithKline (GSK), UK.

Mechanism: Clobetasol propionate binds intracellular steroid receptors in skin cells, suppressing pro-inflammatory cytokines (IL-1, TNF-α), reducing vascular dilation, and exerting local immunosuppression — rapidly reducing rash, redness, and itch.

As a Class I agent, Dermovate is a "last-resort" option for rashes resistant to mild or moderate steroids. Its high potency requires careful, time-limited use.

Dermovate Cream is used for corticosteroid-responsive dermatoses, particularly when rashes are resistant to mild or moderate steroids, including:

• Psoriasis — thick, scaly, chronic plaques (elbows, knees, scalp)
• Chronic eczema/dermatitis — resistant to weaker steroids
• Lichen planus / Lichen simplex chronicus — thickened plaques from chronic scratching
• Discoid lupus erythematosus — chronic circular red plaques
• Steroid-resistant rashes — when Class II–VII agents have failed

Note: Not for fungal infections, acne, or bacterial skin infections — potent steroids can worsen these conditions.

Correct and safe application of Dermovate Cream:

• Cleanse and dry the affected area before applying
• Squeeze a small amount and apply a thin layer just enough to cover the rash
• Gently massage in — do not apply thickly
• Apply 1–2 times daily (morning and evening) or as directed
• Wash hands after each application (unless treating hands)

Recommended duration: No more than 2 consecutive weeks; total weekly dose should not exceed 50 g.

Areas to avoid: Face, eyelids, skin folds (armpits, groin), thin skin areas, and genitals — absorption is higher in these areas, increasing side-effect risk.

Do not occlude (e.g., wrap with plastic film) the treated area — this significantly increases systemic absorption.

As a super-potent steroid, Dermovate Cream can cause side effects if used incorrectly or for too long:

Local side effects (common with prolonged use or on thin skin):

• Skin thinning (atrophy)
• Stretch marks (striae), especially in skin folds
• Permanent visible blood vessels (telangiectasia)
• Skin discoloration / pigment changes
• Rebound flare after stopping

Systemic side effects (rare but significant with extensive/prolonged use):

• Reduced cortisol levels (HPA axis suppression)
• Cushing's syndrome from excess corticosteroid absorption
• Elevated blood sugar (especially in diabetic patients)

If side effects occur, stop use and consult a pharmacist or doctor immediately.

Important precautions (per GSK prescribing information and NHS guidelines):

⚠️ Dermovate is a super-potent steroid. Use short-term as directed. Avoid the face, skin folds, and large surface areas. Do not use continuously without consulting a pharmacist.

Do not use if:

• Skin infection (fungal, bacterial, or viral — e.g., ringworm, herpes, shingles)
• Acne or acne rosacea
• Face, eyelids, or lips
• Open wounds or severely damaged skin
• Children under 1 year old
• Pregnancy — consult a doctor before use

Special caution:

• Diabetic patients — steroids may raise blood sugar levels
• Elderly — already thin skin is at higher risk for side effects
• Children — use with extreme caution, no more than 5–7 days

Intimo Life carries 3 main topical steroids — each differs in potency and indication:

• Dermovate Cream (Clobetasol propionate 0.05%) — Class I super-potent steroid; for thick, resistant, or psoriatic plaques. Use short-term (max 2 weeks).
• Elomet (Mometasone Furoate) — Class III–IV moderate-to-strong steroid; suitable for common inflammatory dermatoses, safer for medium-term use.
• Myda-B (Betamethasone + Clotrimazole) — Moderate steroid combined with antifungal; ideal for rashes with concurrent fungal infection (e.g., severe ringworm, intertriginous candidiasis).

Simple guide: Dermovate = strongest (Class I), short-term for resistant rashes; Elomet = moderate, general inflammatory rashes; Myda-B = moderate + antifungal for rashes with fungal involvement.

Clobetasol propionate in Dermovate Cream acts relatively quickly compared to other steroid classes:

• First 24–48 hours: Visible reduction in redness; itch noticeably improves
• 3–7 days: Plaque begins to flatten; scaling in psoriasis patients decreases significantly
• 1–2 weeks: Most rashes resolve or improve markedly; ~75% of psoriasis patients achieve clearance

Best results when: applied consistently as directed, in a thin layer, without skipping doses.

If no improvement after 2 weeks, consult a doctor or pharmacist — a different treatment approach may be needed.

Drug interactions and co-use considerations for Dermovate Cream:

• Other topical steroids: Do not apply Dermovate together with Elomet or Myda-B on the same area simultaneously — increases side-effect risk without added benefit.
• Oral/injectable corticosteroids: Always inform your pharmacist if using other corticosteroids; combined use raises the risk of HPA axis suppression.
• Moisturisers / emollients: Apply at least 30 minutes apart — apply Dermovate first, then moisturiser.
• Antifungals: If both an anti-inflammatory and antifungal are needed, consider a combination product like Myda-B instead.

Always disclose all medications to a pharmacist before purchasing Dermovate for maximum safety.

Where to buy Dermovate Cream?

Order online at Intimo Life — discreet delivery across Thailand within 1–3 business days. Packaging does not identify the product.