Difelene Gel — topical pain reliever with Diclofenac Diethylammonium (NSAID), penetrates directly to the site of pain
💊 Active: Diclofenac Diethylammonium (Diclofenac) — topical NSAID anti-inflammatory
⏱️ Usage: Apply 3–4 times/day, gently massage until absorbed
🍽️ Condition: External use only, wash hands after application
📦 Pack: 60 g gel tube
⚡ Key benefit: Difelene Gel targets the site directly, fewer stomach side effects than oral NSAIDs
🌡️ Storage: Below 30°C, away from direct sunlight, cap tightly closed
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What is Difelene Gel?
Difelene Gel is a topical NSAID pain-relief gel containing diclofenac diethylammonium. It blocks COX-1 and COX-2 enzymes to reduce prostaglandin production, easing localized pain and inflammation from muscle and joint conditions. Because it works directly at the site of pain, it causes fewer stomach-related side effects than oral NSAIDs. Apply 3-4 times daily, gently massaging until absorbed.
🛒 60g gel tube · Authentic · Fast 24-hr shipping from Intimo Life — consult your doctor or pharmacist before use
Product Description
Difelene Gel is a topical pain reliever and anti-inflammatory containing Diclofenac Diethylammonium — a topical NSAID that inhibits COX-1 and COX-2 cyclooxygenase enzymes, reducing prostaglandin synthesis, the primary mediator of localised pain and swelling. Difelene Gel penetrates the skin directly to the inflamed tissue, delivering targeted relief at the source without requiring digestion or systemic absorption at full therapeutic doses.
📊 Clinical research shows topical diclofenac achieves pain relief comparable to oral NSAIDs for acute musculoskeletal and joint pain, while significantly reducing the risk of gastrointestinal side effects such as gastric ulcers and bleeding
📊 Prevalence of musculoskeletal pain among Thai working-age adults is estimated at 30–40%, driven largely by sedentary occupational habits and sports-related injuries
📊 Diclofenac topical gel at 1% concentration is a widely validated formulation used globally in the management of sprains, tendinitis, bruising, and osteoarthritis
🏭 Manufactured by Difelene to GMP pharmaceutical standards. Each tube contains 60 g of gel. Registration number as shown on product packaging.
⚠️ Individuals with a known allergy to NSAIDs should consult a doctor or pharmacist before using Difelene Gel.
Medically reviewed by
Supatcheree A., Pharmacist | Sources: NHS, NCBI StatPearls, MedlinePlus
Last reviewed: 2026-06-02
About Difelene Gel
What Is Difelene Gel?
Difelene Gel is a topical pain reliever and anti-inflammatory medication containing Diclofenac Diethylammonium — a topical NSAID (Non-Steroidal Anti-Inflammatory Drug) for external use only.
Mechanism of action: Diclofenac penetrates the skin directly into inflamed tissue and inhibits cyclooxygenase enzymes (COX-1 and COX-2), reducing prostaglandin synthesis — the key mediator of inflammation and pain. This results in localised pain relief, reduced swelling, and decreased inflammation at the application site.
Advantage of gel formulation: Because the drug acts locally, systemic blood levels are far lower than with oral NSAIDs, significantly reducing the risk of gastrointestinal, renal, and cardiovascular side effects.
What Does Difelene Gel Treat?
Difelene Gel is indicated for the relief of pain and inflammation in a range of conditions:
Muscle pain — from exercise, heavy work, or physical injury
Bruising — reduces pain and discoloration after impact
Sprains and strains — ankle, wrist, or joint injuries from twisting
Tendinitis — affecting the elbow, shoulder, or Achilles tendon
Acute arthritis — painful joint swelling during flare-ups
Chronic arthritis — such as osteoarthritis of the knee or fingers
Low back pain — from muscle tension or localised inflammation
Difelene Gel is ideal for fast, targeted relief — especially for those who prefer to avoid oral NSAID medications.
How to Use Difelene Gel / Dosage
How to use Difelene Gel:
Apply approximately 2–4 g of gel (about 5–8 cm strip) to the affected area
Spread in a thin layer over the painful or inflamed area and gently massage until absorbed
Use 3–4 times daily as needed, with appropriate intervals between applications
Wash hands thoroughly after applying, unless the hands are the area being treated
Important precautions:
For external use only — do not swallow
Avoid contact with eyes, lips, open wounds, or already-inflamed skin
Do not cover with occlusive dressings (waterproof bandages) after applying, as this may cause excessive absorption
Recommended duration is no more than 2 consecutive weeks; if symptoms do not improve, consult a doctor
Side Effects of Difelene Gel
Since Difelene Gel acts locally, side effects are generally far less common than with oral NSAIDs. However, some reactions may still occur:
Skin reactions (most common):
Redness, burning sensation, or itching at the application site
Systemic side effects (very rare — only with extensive or prolonged misuse):
Mild gastrointestinal symptoms such as nausea
Systemic allergic reaction (rare) such as hives
If you experience a severe allergic reaction — hives, facial swelling, difficulty breathing — stop using the gel immediately and seek medical attention.
Contraindications & Precautions
Do not use Difelene Gel if you:
Are allergic to diclofenac or other NSAIDs (e.g. ibuprofen, naproxen)
Are allergic to aspirin or have NSAID-induced asthma
Have open wounds, burns, or chronic skin inflammation at the application site
Need to apply near the eyes, mouth, or mucous membranes
Special precautions:
Third trimester of pregnancy: Contraindicated — NSAIDs may cause premature closure of the ductus arteriosus
First/second trimester and breastfeeding: Consult a doctor before use
Children under 14: Not recommended without medical advice
Elderly patients: Use with care; monitor for skin reactions
Avoid direct sunlight on treated areas — diclofenac may increase photosensitivity
Difelene Gel vs Other Topical Pain Relievers
Intimo Life offers several topical pain relief options depending on your symptoms and preferred mechanism:
Namman Muay (Menthol + Methyl Salicylate) — warming oil for muscle relaxation; suitable for general fatigue, not true inflammation
In summary: Choose Difelene Gel for targeted NSAID gel relief; Uniren Spray for convenient spray-on diclofenac; Reparil for bruising and venous swelling (aescin); Namman Muay for warming muscle massage.
Can Difelene Gel Be Used With Other Medications?
Because Difelene Gel is partially absorbed through the skin, drug interactions are possible, though less likely than with oral NSAIDs:
Anticoagulants (Warfarin, heparin): Use with caution — diclofenac may potentiate anticoagulant effects even when applied topically
Oral NSAIDs: Avoid using simultaneously — combination increases the risk of side effects
Immunosuppressants (Cyclosporine): Consult your doctor before combining
Diuretics: Diclofenac may reduce diuretic efficacy in some patients
If you are taking multiple medications, inform your pharmacist or doctor before starting Difelene Gel.
How Quickly Does Difelene Gel Work?
Difelene Gel typically begins to relieve pain within 30–60 minutes of application. The speed of onset depends on:
Skin thickness at the application site (thinner skin absorbs faster)
Amount applied and massage technique to enhance absorption
Severity of pain or inflammation
For chronic conditions such as osteoarthritis, consistent use over 7–14 days is often needed for optimal improvement. Acute injuries such as sprains and bruises typically show improvement within 2–3 days.
Apply Difelene Gel regularly (3–4 times daily) to maintain consistent tissue levels for best results.
Where to Buy Difelene Gel?
Where to Buy Difelene Gel?
Order Difelene Gel online at Intimo Life. Fast delivery across Thailand in 1–3 business days, packed discreetly with no product name on the outer box.
Difelene Gel contains Diclofenac Diethylammonium — a topical NSAID. Unlike paracetamol, it actively reduces inflammation in addition to blocking pain signals. Unlike oral NSAIDs, it does not pass through the digestive system, so stomach-related side effects are much less likely.
Difelene Gel relieves muscle pain, bruising, sprains, tendinitis, acute and chronic arthritis (including osteoarthritis), and lower back pain of muscular or joint origin. It provides targeted localised relief directly at the site of pain.
Difelene Gel is considered safe when used as directed, as only a small amount of the active ingredient enters the bloodstream. Daily use 3–4 times is fine, but do not continue for more than 2 consecutive weeks without consulting a doctor. Those with NSAID allergy or in the third trimester of pregnancy should avoid it.
Difelene Gel is strictly contraindicated in the third trimester of pregnancy, as NSAIDs may affect fetal blood vessels. During the first or second trimester and while breastfeeding, always consult a doctor or pharmacist before use.
Difelene Gel contains Diclofenac (an NSAID) for strong anti-inflammatory and analgesic action — best for arthritis, tendinitis, and muscle pain. Reparil Gel-N uses Aescin + Diethylamine Salicylate to reduce swelling and strengthen venous walls — more suited for bruising, swelling, and venous inflammation.
Yes, but wait at least 10–15 minutes for the gel to absorb into the skin, and avoid washing the area immediately after application. It is not advisable to exercise intensively while experiencing significant pain, as this may worsen the injury. Allow adequate recovery time first.
Difelene Gel is not recommended for children under 14 years of age without medical supervision, as safety data in young children is limited.
Avoid direct sunlight on the area where Difelene Gel has been applied. Diclofenac may increase photosensitivity, making the skin more prone to irritation or sunburn. If sun exposure is unavoidable, cover the treated area.
Store Difelene Gel below 30°C, away from heat and direct sunlight. Do not refrigerate. Always replace the cap tightly after use, and check the expiry date on the tube before each application.
Related Products
Products with the same active ingredient or treating the similar condition.
Reparil Gel-N
Uniren Spray
Arotika Pain Relief Spray
Namman Muay
Voltaren Emulgel