Omeprazole GPO

Omeprazole GPO is an acid-reducing medication in the Proton Pump Inhibitor (PPI) class, manufactured by the Government Pharmaceutical Organization (GPO) of Thailand. Its active ingredient is Omeprazole, a highly effective drug for treating Gastroesophageal Reflux Disease (GERD), stomach and duodenal ulcers, and various hyperacidity conditions.

The medication comes in enteric-coated capsule form, designed to protect the active ingredient from being destroyed by stomach acid, allowing it to work at full effectiveness.

Omeprazole specifically inhibits the H+/K+-ATPase enzyme (Proton Pump) on the surface of gastric parietal cells, which is the final step in acid production.

• Proton Pump Inhibition: Significantly reduces acid production in the stomach, relieving heartburn, stomach pain from ulcers, and acid reflux symptoms
• Long-lasting Effect: Inhibits acid secretion for up to 24 hours per dose
• Absorption: The drug is rapidly absorbed and metabolized in the liver (via CYP2C19 and CYP3A4), primarily excreted through urine

For Adults and Children 12 Years and Older:

• Take once daily, 30-60 minutes before breakfast
• Swallow the capsule whole. Do not crush, chew, or open the capsule
• Can be taken with plain water
• If symptoms are severe, the doctor may adjust the dosage accordingly

For Children Under 12 Years:

• Must be under medical supervision only
• Dosage is calculated based on body weight. Do not adjust dosage on your own

For Patients with Liver Disease:

• Patients with severe liver disease may need dose reduction. Consult a doctor before use

For Patients with Kidney Disease and Elderly:

• Generally no dose adjustment needed, but should be used under medical guidance

If You Miss a Dose:

• Take it as soon as you remember
• If it's almost time for the next dose, skip the missed dose
• Never take a double dose

Common Side Effects:

• Headache
• Diarrhea
• Nausea
• Stomach pain
• Constipation
• Bloating

Side Effects Requiring Immediate Medical Attention:

• Severe allergic reactions (rash, swelling, difficulty breathing)
• Severe and persistent diarrhea (may indicate C. difficile infection)
• Signs of low magnesium (muscle spasms, seizures)

Long-term Use Side Effects:

• Increased risk of intestinal infections
• Low blood magnesium levels
• Increased risk of osteoporosis (especially in elderly patients using for more than 1 year)

Contraindications:

• Those allergic to Omeprazole or other PPIs such as Esomeprazole, Lansoprazole
• Those currently taking Nelfinavir (HIV antiviral medication)
• Children under 1 year old (unless under specialist supervision)

Things to Avoid:

• Alcohol — stimulates acid secretion and reduces drug effectiveness
• Certain antifungal medications such as Ketoconazole — may reduce drug absorption

Special Precautions:

• This medication may cause drowsiness in some patients. Avoid driving or operating machinery if affected
• If self-treating and symptoms don't improve within 14 days, stop the medication and consult a doctor
• Pregnant and breastfeeding women should consult a doctor before use

Drug Interactions:

• Clopidogrel (antiplatelet medication)
• Warfarin (blood thinner)
• Diazepam
• Certain antifungal medications

Omeprazole GPO is a dangerous drug category medication. You can purchase it online at Intimo Life by registering as a member and consulting with a pharmacist before ordering. This ensures you receive the appropriate and safe medication. Fast delivery throughout Thailand.

What's the Difference Between Omeprazole GPO and Nexium (Esomeprazole)?

Esomeprazole is the S-isomer of Omeprazole. Some studies show it may be slightly more effective in certain cases, but generally both have similar effectiveness in treating acid reflux.

Can Omeprazole GPO Be Used to Treat H. pylori Infection?

Yes, when used in combination with antibiotics as prescribed by a doctor to eradicate Helicobacter pylori bacteria that cause stomach disease.

Does Omeprazole GPO Cause Weight Gain?

There's no clear evidence that this medication causes weight gain. However, some people may feel increased appetite when stomach pain or heartburn improves.

Can Omeprazole GPO Be Used with Blood Pressure Medications?

Generally, they can be used together, but you should inform your doctor or pharmacist about all medications you're currently taking.

Do I Need to Stop Omeprazole GPO Before Surgery?

Generally not necessary, but you should inform the surgeon that you're taking this medication.

Can Omeprazole GPO Be Used to Prevent Heartburn Before Eating Spicy Food?

This medication is not designed for occasional use. It should only be used as directed by a doctor or pharmacist.

Does Omeprazole GPO Affect Vitamin Absorption?

Long-term use of PPIs may reduce absorption of vitamin B12 and magnesium. Consult a doctor if using the medication continuously for a long time.

Can Omeprazole GPO Be Used in Diabetic Patients?

Yes, this medication doesn't directly affect blood sugar levels. However, you should inform your doctor about any diabetes medications you're taking.

Why Does Omeprazole GPO Need to Be a Special-Coated Capsule?

Because Omeprazole is destroyed by stomach acid. The special coating allows the medication to pass through the stomach and be absorbed in the small intestine completely.

What Should I Do If I Vomit After Taking Omeprazole GPO?

If you vomit within 30 minutes of taking the medication, you may take another dose. If more than 30 minutes have passed, there's no need to take another dose.

1. Omeprazole - DrugBank
2. Omeprazole - MedlinePlus
3. Omeprazole - NHS UK
4. Proton Pump Inhibitors - StatPearls NCBI
5. Omeprazole - Drugs.com
6. Thai FDA (สำนักงานคณะกรรมการอาหารและยา)