Flunarizine

Flunarizine is a selective calcium channel blocker that acts specifically on brain tissue and the vestibular system. It inhibits the influx of calcium ions through voltage-gated calcium channels in vessel walls, preventing pathological vasoconstriction — a key mechanism behind migraine attacks and vertigo episodes. It also possesses mild antiserotonin and antihistamine properties that contribute to migraine control. Importantly, Flunarizine is NOT an acute pain reliever; it must be taken continuously as a preventive treatment to reduce the frequency and severity of attacks over time.

Flunarizine has two main medically approved indications:

• Migraine Prophylaxis — for patients with recurring migraines (2 or more per month) or attacks severe enough to impair daily function. Taken nightly to reduce frequency and severity of migraines over the long term.
• Vertigo — for vertigo caused by vascular dysfunction in the vestibular system. Relieves spinning sensation, nausea, vomiting, and balance disturbance by improving blood flow to the inner ear.

Note: Flunarizine is NOT an acute migraine reliever (triptans or NSAIDs are used for that) and is not appropriate for all types of dizziness. Consult a pharmacist to confirm the right indication before use.

Standard dosage and administration for Flunarizine 5 mg:

• Adults: 5–10 mg at bedtime each night (evening dosing reduces daytime drowsiness side effects)
• Elderly (>65 years): Start at 5 mg at bedtime to minimize side effect risk
• Duration: At least 3 continuous months required to see clear migraine prevention benefit
• For vertigo: Shorter treatment duration depending on clinical response

Caution: Do not stop abruptly without consulting a doctor or pharmacist. Take at the same time each night for stable blood levels. If a dose is missed, skip it and resume the next night — never double dose.

Common side effects of Flunarizine:

• Drowsiness / sedation — most common at treatment start; bedtime dosing minimizes daytime impact
• Weight gain — due to antihistamine properties; common with long-term use
• Depression / mood changes — rare, but stop and see a doctor immediately
• Parkinson-like symptoms — tremor, rigidity, abnormal gait — stop immediately and seek medical attention

Do not use if you have a history of Parkinson's disease or depression. Report any unexpected neurological changes to a doctor immediately.

Both Flunarizine and Betahistine treat vertigo, but via different mechanisms:

• Flunarizine — calcium channel blocker; prevents cerebrovascular constriction; suits migraine prevention AND vascular vertigo; bedtime once daily
• Betahistine — histamine analogue; directly increases inner ear blood flow; best for Meniere's disease and vestibular vertigo; 3 times daily

Vertigo with migraines → flunarizine preferred. Meniere's-type vertigo (tinnitus + hearing changes) → betahistine preferred. Consult a pharmacist for the right choice.

Contraindications and important precautions for Flunarizine:

• Parkinson's disease — absolutely contraindicated; Flunarizine can significantly worsen Parkinson's symptoms
• History of depression or psychiatric disorders — contraindicated or use only under strict medical supervision
• Pregnancy and breastfeeding — insufficient safety data; not recommended
• Children under 12 years — not recommended; insufficient safety data
• Drivers and machine operators — use caution due to drowsiness; avoid driving especially at the start of treatment

Flunarizine must be used under the guidance of a doctor or licensed pharmacist. At Intimo Life, you can consult a pharmacist online and order conveniently, safely, and privately — no need to travel to a hospital or pharmacy.

• Always consult a licensed pharmacist before ordering to confirm indication and appropriate dosage
• Delivered directly to your door in plain, confidential packaging
• For more information about migraine medications or to compare other migraine prevention options, visit our migraine treatment collection