Period Pain Relief
Ponstan
Ponstan — A trusted period pain reliever that women have relied on for years, effectively easing menstrual cramps and discomfort.
💊 Mefenamic Acid 500 mg — An NSAID that works to reduce inflammation and relieve pain effectively
🩸 Ideal for menstrual pain — Targets period cramps and lower abdominal discomfort directly
⏱️ Fast-acting relief — Start feeling better within 30-60 minutes after taking
📦 1 box contains 10 tablets — 500 mg per tablet, easy to carry
✅ A familiar choice — A widely used period pain medication trusted by women for years
การจัดส่งสินค้า
จัดส่งสินค้าอย่างเป็นส่วนตัวภายในประเทศไทย โดยบรรจุภัณฑ์ไม่ระบุรายละเอียดสินค้า ลูกค้าสามารถตรวจสอบเงื่อนไขการจัดส่งและการคืนสินค้าได้ตามนโยบายของร้าน หากมีข้อสงสัยสามารถติดต่อทีมงานเพื่อขอข้อมูลเพิ่มเติม
Product Description
Menstrual pain medication is widely used by women to relieve period cramps. Ponstan is an NSAID (Fenamate) painkiller containing Mefenamic Acid 250 mg / 500 mg, which reduces pain and inflammation. It is the most popular menstrual pain medication in Thailand, manufactured by Pfizer.
📊 Key Statistics
- Dysmenorrhoea (menstrual pain) affects more than 50–80% of women, especially teenagers and women of reproductive age
- Mefenamic Acid inhibits COX-1 and COX-2 enzymes, reducing Prostaglandin production — the primary cause of menstrual pain
- Ponstan is one of the earliest and most well-known menstrual pain brands in Thailand, used for decades
- See other pain relievers in the Pain Relief collection
🏭 Ponstan is manufactured by Pfizer, a global pharmaceutical company. It is the originator brand of Mefenamic Acid, Thai FDA approved, with a long track record of reliability.
⚠️ Always take this medication after or with food to reduce stomach irritation. Do not use for more than 7 consecutive days.
About Ponstan
What is Ponstan?
Ponstan is a Non-Steroidal Anti-Inflammatory Drug (NSAID) of the Fenamate class, containing Mefenamic Acid as its active ingredient, available in 250 mg and 500 mg strengths. Manufactured by Pfizer.
Mefenamic Acid works by inhibiting Cyclooxygenase (COX-1 and COX-2) enzymes, reducing Prostaglandin production — the substance responsible for pain, inflammation, and uterine contractions — effectively relieving menstrual pain.
Beyond COX inhibition, Mefenamic Acid also acts as a direct Prostaglandin Antagonist — a unique property of the Fenamate class not found in typical NSAIDs — making it particularly effective for menstrual pain.
Ponstan is the originator brand of Mefenamic Acid by Pfizer, used worldwide for decades.
What is Ponstan used for?
Dysmenorrhoea (menstrual pain): Ponstan is a first-line treatment for menstrual pain. Mefenamic Acid reduces both Prostaglandin (the cause of uterine contractions) and excessive menstrual bleeding.
Other indications:
- Headache, toothache (mild to moderate pain)
- Muscle pain, joint pain
- Post-operative and post-procedural pain
- General inflammatory pain
- Menorrhagia (heavy menstrual bleeding)
Not for: Long-term chronic pain such as rheumatoid arthritis (other NSAIDs may be more appropriate). Do not use for more than 7 consecutive days.
How to Take Ponstan / Dosage
Dosage for menstrual pain:
- Initial dose: Mefenamic Acid 500 mg (one 500 mg tablet or two 250 mg tablets)
- Then: 250 mg every 6 hours or 500 mg every 8 hours as needed
- Maximum dose: 1,500 mg/day
Important:
- Always take after or with food to reduce stomach irritation
- Swallow whole with water
- Do not use for more than 7 consecutive days
Tip: For menstrual pain, start taking it from the first day of pain or the first day of your period for best results — don't wait until pain becomes severe.
Side Effects of Ponstan
Common side effects:
- Abdominal pain, nausea, vomiting
- Diarrhoea (more common than other NSAIDs)
- Indigestion, heartburn
- Headache, dizziness
Serious side effects (rare):
- Stomach ulcers, gastrointestinal bleeding (GI bleeding)
- Kidney problems, especially in those with pre-existing kidney disease
- Severe allergic reaction (Anaphylaxis) — rash, swelling, difficulty breathing
- Haemolytic Anaemia (very rare)
When to stop and see a doctor:
- Black or bloody stools
- Vomiting blood
- Allergic reactions such as rash, facial swelling, or difficulty breathing
- Abnormally reduced urination
Contraindications & Precautions
Do not use:
- Allergy to Mefenamic Acid, Aspirin, or other NSAIDs
- Active stomach ulcers or gastrointestinal bleeding
- Severe kidney disease
- Severe liver disease
- Third trimester of pregnancy (may cause premature closure of Ductus Arteriosus)
- Children under 14 years (for 500 mg strength)
Use with caution:
- Always take after food — never on an empty stomach
- Do not use for more than 7 consecutive days
- Elderly patients have higher risk of gastrointestinal and kidney side effects
- Watch for interactions with Warfarin, Lithium, Methotrexate, ACE Inhibitors
- Avoid alcohol — increases risk of stomach bleeding
How Does Ponstan Compare to Other Pain Relievers?
Ponstan with Nexium (combined use): If using Ponstan regularly, doctors may recommend taking Nexium (Esomeprazole) or another acid reducer to prevent stomach ulcers from NSAID use.
Ponstan vs. Ibuprofen: Both are NSAIDs, but Ponstan has additional direct Prostaglandin antagonist properties, making it more effective for menstrual pain. Ibuprofen is more widely available, cheaper, and more versatile.
Ponstan vs. Paracetamol: Paracetamol relieves pain but does not reduce inflammation or Prostaglandin. Ponstan is significantly more effective for menstrual pain as it targets the root cause. However, Paracetamol is gentler on the stomach.
How Long Does Ponstan Take to Work?
Ponstan starts working within 30–60 minutes of taking it. Mefenamic Acid is well absorbed from the gastrointestinal tract.
Duration of action:
- Onset: 30–60 minutes
- Peak blood levels: 2–4 hours
- Pain relief duration: Approximately 6 hours
- Half-life: Approximately 2 hours
Tips for menstrual pain:
- Start taking it from the first day of pain or the first day of your period
- Take regularly every 6–8 hours — don't wait until pain becomes severe
- Usually only 2–3 days of use is sufficient for the most painful days
Where Can I Buy Ponstan?
Ponstan is a pharmacist-dispensed medication. You can order online from Intimo Life.
Can I buy Ponstan online?
Yes. Order through Intimo Life — select the product, consult with a licensed pharmacist online, and receive your medication at home.
Do I need a prescription?
A doctor's prescription is not required, but the medication must be dispensed by a licensed pharmacist. At Intimo Life, our pharmacist will review your symptoms and health history to confirm suitability before shipping.
How does Intimo Life ship orders?
We deliver nationwide in Thailand with discreet packaging — no product names on the outside.
⚠️ ข้อจำกัดความรับผิดชอบ
เนื้อหาในบทความนี้มีจุดประสงค์เพื่อให้ความรู้ทั่วไปเท่านั้น ไม่ได้มีเจตนาทดแทนคำแนะนำ การวินิจฉัย หรือการรักษาจากแพทย์หรือเภสัชกรผู้เชี่ยวชาญ หากมีข้อสงสัยเกี่ยวกับอาการหรือการใช้ยา ควรปรึกษาแพทย์หรือเภสัชกรก่อนเสมอ
Frequently Asked Questions
No. Never take Ponstan on an empty stomach. Mefenamic Acid is highly irritating to the stomach lining and may cause stomach pain, nausea, or ulcers. Always take it after or with food.
For menstrual pain specifically, Ponstan (Mefenamic Acid) is often more effective because it has both COX inhibition and direct Prostaglandin antagonist properties — the main cause of menstrual cramps. Ibuprofen is a good general painkiller and more widely available, but Ponstan typically works better for period pain.
Do not use Ponstan for more than 7 consecutive days, as it increases the risk of stomach and kidney side effects. For menstrual pain, 2–3 days is usually sufficient. If you need pain relief frequently, consult your doctor.
Ponstan is strictly contraindicated in the third trimester of pregnancy as it may cause premature closure of the foetal Ductus Arteriosus. It should also be avoided in the first and second trimesters unless prescribed by a doctor. Paracetamol is a safer alternative for pain during pregnancy.
Diarrhoea is a more common side effect with Mefenamic Acid than other NSAIDs. It occurs due to Prostaglandin inhibition in the intestines, altering bowel movement. If diarrhoea is severe or persistent, stop the medication and consult a pharmacist about switching to a different painkiller.
Yes. Ponstan (Mefenamic Acid) and Paracetamol work through different mechanisms and can be safely combined for enhanced pain relief. However, do not combine Ponstan with other NSAIDs such as Ibuprofen, Diclofenac, or Naproxen, as this increases the risk of stomach side effects.
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