Nexium

Nexium is a Proton Pump Inhibitor (PPI) medication containing Esomeprazole as its active ingredient, manufactured by AstraZeneca. It is the original brand that is globally recognized for treating acid reflux disease and stomach ulcers.

Esomeprazole is the S-isomer of Omeprazole, which has the advantage of slower metabolism in the body, resulting in higher and more consistent blood levels. This leads to more effective and predictable acid suppression compared to first-generation PPIs.

Nexium acts as a Selective Proton Pump Inhibitor with the following mechanism:

• Inhibits H+/K+-ATPase enzyme (Proton Pump) — Specifically and irreversibly blocks the proton pump in stomach parietal cells
• Reduces acid secretion in both normal and stimulated conditions — Relieves heartburn and prevents ulcer formation
• Effective for up to 24 hours — Allows once-daily dosing
• Rapidly absorbed — Metabolized in the liver primarily through CYP2C19 and CYP3A4 enzymes

For Adults and Children Over 12 Years:

• GERD: Once daily for 4-8 weeks
• Stomach Ulcer Treatment: Once daily for 4-8 weeks
• NSAID Ulcer Prevention: Once daily as directed by physician

How to Take:

• Take at least 30-60 minutes before the first meal of the day (breakfast)
• Swallow whole with water. Do not chew, crush, or break the tablet as it has a special coating
• Not recommended to take with food as it may reduce absorption

For Children 1-12 Years:

• Must be under specialist physician supervision only
• Dosage depends on body weight and indication

For Patients with Liver Disease:

• Patients with severe liver impairment (Child-Pugh C) should have maximum dose reduced to no more than 20 mg per day

For Patients with Kidney Disease:

• No dose adjustment necessary

If You Miss a Dose:

• Take it as soon as you remember
• If it's almost time for the next dose, skip the missed dose
• Do not double the dose

Common Side Effects:

• Headache
• Diarrhea
• Abdominal pain
• Nausea
• Constipation
• Flatulence
• Dizziness (uncommon)

Side Effects from Long-term Use (More than 1 Year):

• Vitamin B12 deficiency
• Low magnesium levels (Hypomagnesemia)
• Increased risk of bone fractures (hip, wrist, spine)

Symptoms Requiring Immediate Medical Attention:

• Severe allergic reactions (rash, swelling, difficulty breathing)
• Severe and persistent diarrhea (may indicate C. difficile infection)
• Acute interstitial nephritis

Contraindications:

• Allergy to Esomeprazole or other PPIs (such as Omeprazole, Lansoprazole)
• Patients taking Rilpivirine (HIV antiviral medication)
• Children under 1 year (unless under specialist supervision)

Medications to Avoid:

• Antivirals (such as Rilpivirine, Atazanavir)
• Antifungals (such as Ketoconazole, Itraconazole)
• Antiplatelet drugs (such as Clopidogrel)

Precautions:

• Do not use for more than 14 consecutive days without medical supervision
• If symptoms don't improve within 1-2 weeks, stop and consult a doctor
• Avoid alcohol while taking this medication
• Pregnant and breastfeeding women should consult a doctor before use
• Stopping suddenly after long-term use may cause Rebound Acid Hypersecretion

You can buy Nexium online at Intimo Life. Registration and pharmacist consultation are required before purchase to ensure you receive the appropriate medication that is safe for your use.

When is the Best Time to Take Nexium?

Take it at least 30-60 minutes before breakfast for maximum effectiveness in inhibiting acid secretion.

How Long Until Nexium Works?

Heartburn symptoms usually improve within 2-3 days, but healing esophageal or stomach ulcers may take 4-8 weeks.

How is Nexium Different from Omeprazole?

Nexium (Esomeprazole) is the S-isomer of Omeprazole with more consistent metabolism, resulting in stable blood levels and better acid control.

Can I Take Nexium with Milk?

Not recommended. Take on an empty stomach before meals for best absorption.

Can Nexium Prevent Ulcers from Pain Medications?

Yes, Nexium is indicated for preventing and treating stomach ulcers caused by NSAIDs in high-risk patients.

Can I Stop Nexium Suddenly?

If you've been taking it long-term, stopping suddenly may cause Rebound Acid Hypersecretion. Consult your doctor to gradually reduce the dose.

Can I Take Nexium with Blood Pressure Medication?

Inform your doctor or pharmacist about all medications you're taking, as there may be drug interactions.

Does Nexium Cause Weight Gain?

There are no reports that Nexium directly causes weight gain. Consult your doctor if you have concerns.

Can I Take Nexium Before Bed?

Not recommended. Take before breakfast for best results, as proton pumps are most active in the morning.

Can I Store Nexium in the Refrigerator?

Not necessary. Store at room temperature below 30°C in a dry place, away from moisture and sunlight.

1. FDA - Nexium (Esomeprazole Magnesium) Label
2. Mayo Clinic - Esomeprazole (Oral Route)
3. NHS - Esomeprazole
4. MedlinePlus - Esomeprazole
5. Drugs.com - Nexium
6. UpToDate - Esomeprazole: Drug Information
7. Thai FDA - Drug Database