Sumigran

Sumigran is a migraine medication in the 5-HT1 receptor agonist class, commonly known as "Triptan." Its active ingredient is Sumatriptan, manufactured by Siam Pharmaceutical Co., Ltd.

This medication is used for treating acute migraine attacks, both with and without aura, including menstrual-related migraines. It works within 30-60 minutes after taking.

Important: This medication is only for treating migraines that have already started. Do not use it to prevent migraines.

Sumatriptan in Sumigran works as a Selective Serotonin (5-HT1B/1D) receptor agonist with the following mechanism:

• Inhibits 5-HT1B/1D receptors in brain blood vessels
• Causes abnormally dilated blood vessels in the brain to constrict back to normal
• Inhibits the release of pain-triggering neurotransmitters
• Reduces migraine headache, nausea, and sensitivity to light/sound

The drug is rapidly absorbed and metabolized in the liver, then excreted primarily through urine.

For Adults and Children 18 Years and Older

• Take 1 tablet immediately when migraine headache starts
• Can be taken with or without food
• If symptoms return, you can take another dose after at least 2 hours
• Maximum dose: 200 mg in 24 hours
• Do not use more than 10 days per month to prevent medication overuse headache

For Children Under 18 Years

• Not recommended due to insufficient safety and efficacy data
• If necessary, consult a specialist physician

For Patients with Liver Disease or Elderly Patients

• Start with a low dose and monitor closely
• Patients with mild to moderate liver disease require dose reduction
• Do not use in patients with severe liver disease
• Elderly patients should use with caution due to higher cardiovascular risk

For Migraine with Aura

• Wait until the aura phase (e.g., seeing zigzag lights) has passed
• Start taking the medication when headache begins

If the First Tablet Doesn't Work

• If symptoms don't improve at all within 2 hours after the first tablet, do not take another dose for that attack
• Consult a doctor to evaluate other options

Common Side Effects

• Dizziness, flushing, fatigue
• Feeling of pressure or tightness in the chest, throat, or jaw (Triptan sensations) — generally not dangerous and will resolve on its own
• Nausea, vomiting
• Drowsiness — avoid driving or operating machinery after taking

Symptoms Requiring Immediate Medical Attention

• Severe and persistent chest pain
• Severe allergic reaction (Anaphylaxis)
• Symptoms of Serotonin Syndrome — confusion, hallucinations, rapid heartbeat

Contraindications

• Allergy to Sumatriptan or other Triptans
• Ischemic heart disease
• Uncontrolled high blood pressure
• History of stroke
• Severe liver disease
• Children under 18 years

Medications That Must Not Be Used Together

• Ergotamine medications (e.g., Cafergot): Do not use within 24 hours as it may cause severe vasoconstriction
• Other Triptans: Do not use within 24 hours
• MAOIs: Do not use together or within 2 weeks after stopping

Medications Requiring Caution

• SSRIs/SNRIs (antidepressants): May increase risk of Serotonin Syndrome; monitor for unusual symptoms

Things to Avoid

• Alcohol: Increases risk of side effects and may trigger headaches

Pregnancy and Breastfeeding

• Pregnancy: Not recommended unless the doctor determines benefits outweigh risks
• Breastfeeding: Avoid breastfeeding for 12 hours after taking the medication

You can order Sumigran online at Intimo Life. Customers must register and consult with our pharmacist first to ensure the medication is appropriate for their health condition and that there are no contraindications. After approval, you can place orders directly through our website.

Can Sumigran prevent migraines?

No. Sumigran is only for treating migraine attacks that have already started. Do not use it to prevent migraines.

Can Sumigran treat tension headaches?

No. This medication works specifically for migraines only. It is not effective for tension headaches.

Can I take Sumigran with paracetamol?

Generally, you can take it with paracetamol without significant drug interactions.

How is Sumigran different from Cafergot?

Sumigran (Triptan) has more targeted action than Cafergot (Ergotamine), resulting in fewer side effects like nausea and vomiting, but has its own specific side effects such as chest tightness.

Is Sumigran addictive?

Sumigran is not addictive. However, using it too frequently may lead to Medication Overuse Headache.

Can I split Sumigran tablets?

Since it's a film-coated tablet, splitting or crushing is not recommended. Swallow the whole tablet with water.

• Sumatriptan - StatPearls (NCBI)
• Sumatriptan - MedlinePlus
• Sumatriptan - Drugs.com
• Thai FDA

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