Biocalm

Biocalm is a muscle relaxant manufactured by Biolab Co., Ltd. in Thailand. Its active ingredient is Tolperisone Hydrochloride, classified as a Centrally Acting Muscle Relaxant.

Tolperisone was first developed in Hungary in the 1960s and has been widely used across Europe, Asia, South America, and Africa for decades. In Thailand, Biocalm is registered as a dangerous drug (Registration No. 1A 14/56), meaning it must be dispensed by a physician or pharmacist only.

Biocalm is used to relieve muscle pain, muscle inflammation, and muscle spasms from various causes, including:

• Low back pain — One of the most common complaints among working adults
• Neck, shoulder, and upper back stiffness — Often caused by prolonged sitting or office syndrome
• Spondylosis — A degenerative condition commonly found in older adults
• Arthrosis — Pain and stiffness in large joints
• Post-stroke spasticity — Helps reduce abnormally increased muscle tone, improving mobility
• Muscle spasms from other neurological conditions — Such as multiple sclerosis and myelopathy, as determined by a physician

Tolperisone works by inhibiting Voltage-Gated Sodium Channels and Calcium Channels in the nervous system, resulting in:

• Reduced nerve signal transmission causing muscle contraction — By inhibiting neuronal activity in the spinal cord and reticular formation, reducing polysynaptic spinal reflexes, allowing muscles to relax
• Reduced pain from muscle spasms — As muscles relax, pressure on surrounding nerves and tissues decreases
• Less sedation than older muscle relaxants — Because Tolperisone does not significantly affect the cerebral cortex and has fewer anticholinergic side effects (dry mouth, blurred vision) compared to older muscle relaxants like Orphenadrine

The drug is rapidly absorbed from the gastrointestinal tract, takes effect within approximately 30-60 minutes, reaches peak blood concentration within 1.5 hours, and is metabolised in the liver before being excreted primarily through the kidneys, with a first-phase half-life of approximately 2 hours and a second-phase half-life of approximately 12 hours.

For Adults (18 years and older)

• Take 1-3 tablets, 3 times daily, immediately after meals
• Start with a low dose and gradually increase as recommended by a physician or pharmacist
• Swallow whole with water — do not break, crush, or chew as it is a film-coated tablet
• Do not use continuously for more than 3-5 days without consulting a physician
• If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose. Never double the dose

For Children (Under 18 years)

• Not recommended for children under 18 years due to insufficient safety and efficacy data

For Elderly / Patients with Liver or Kidney Disease

• Consult a physician for dose adjustment, as the drug is metabolised in the liver and excreted through the kidneys. Impaired organ function may lead to drug accumulation

Side effects occur in fewer than 1% of users and are generally reversible upon discontinuation.

Possible side effects:

• Nervous system — Fatigue, headache, dizziness
• Gastrointestinal — Nausea, stomach discomfort, dry mouth
• Cardiovascular — Low blood pressure (rare)
• Musculoskeletal — Muscle weakness (rare)

Stop taking the medication and seek medical attention immediately if you experience:

• Skin rash, itching, swelling of the face or throat
• Difficulty breathing, wheezing
• Severe drop in blood pressure, fainting
• Anaphylaxis — Although very rare (less than 0.1%), this is a serious reaction to watch for

Do not use if:

• You have a history of allergy to Tolperisone or structurally similar drugs such as Eperisone
• You have Myasthenia Gravis
• You have severe liver or kidney impairment
• You are pregnant or breastfeeding — Insufficient safety data available

Precautions:

• Avoid alcohol — May enhance CNS depressant effects, increasing drowsiness or dizziness
• Be cautious when driving — Although less sedating than older alternatives, some users may still experience drowsiness, especially when first starting the medication
• Be cautious when combining with other CNS depressants — Such as benzodiazepines, sleeping pills, or opioid painkillers, as they may enhance each other's effects
• Always inform your physician or pharmacist — About all existing medical conditions and medications before starting Biocalm

Biocalm is classified as a dangerous drug under Thai law and must be dispensed by a physician or pharmacist only. You can buy it online at Intimo Life by registering as a member and consulting with our pharmacist online. Once approved, you can place your order directly through our website, with fast delivery and discreet packaging to protect your privacy.

Can Biocalm be used for office syndrome?

Yes, Biocalm can help relieve muscle pain and stiffness in the neck, shoulders, and upper back associated with office syndrome. However, it should be used alongside ergonomic adjustments and physical therapy for the best results.

What is the difference between Biocalm and Mydocalm?

Both contain the same active ingredient, Tolperisone, but are manufactured by different companies — Biocalm by Biolab (Thailand) and Mydocalm by Gedeon Richter (Hungary). Their efficacy and indications are the same.

What is the difference between Biocalm (Tolperisone) and Eperisone?

Both Tolperisone and Eperisone are centrally acting muscle relaxants with similar chemical structures, efficacy, and side effect profiles. The choice between them depends on the physician's judgement and individual patient response.

Can Biocalm be used for menstrual cramps?

No. Biocalm is a muscle relaxant, not a general painkiller. For menstrual cramps, NSAIDs such as Ibuprofen or Mefenamic Acid are more appropriate.

Can Biocalm tablets be split or crushed?

No. Biocalm is a film-coated tablet and should not be broken, crushed, or chewed, as this may affect drug release and absorption. Swallow whole with water.

Can people with high blood pressure use Biocalm?

Generally yes, but inform your physician or pharmacist, as the drug may cause low blood pressure in some individuals. Close monitoring is recommended.

Can Biocalm be taken with Paracetamol?

Yes. Tolperisone has minimal clinically significant drug interactions, and Paracetamol is not in the group of drugs that require caution. However, always consult a pharmacist before combining multiple medications.

Can I drive after taking Biocalm?

Although Tolperisone causes less sedation than older muscle relaxants, observe how you feel when first starting the medication. If you do not experience drowsiness or dizziness, you can drive normally. Research from Neurana Pharmaceuticals found that Tolperisone did not impair driving performance compared to placebo.

What happens if I take too much Biocalm?

Overdose may cause severe drowsiness, unsteady gait, significant muscle weakness, confusion, or low blood pressure. There is no specific antidote. If overdose is suspected, seek medical attention immediately.

Is Biocalm addictive?

No. Tolperisone is not classified as a narcotic or psychotropic substance. It does not cause addiction or withdrawal symptoms upon discontinuation.

• Tolperisone: A Typical Representative of a Class of Centrally Acting Muscle Relaxants with Less Sedative Side Effects — PMC (NIH)
• Basic Aspects of the Pharmacodynamics of Tolperisone — PMC (NIH)
• Tolperisone — Wikipedia
• Tolperisone: Uses, Interactions, Mechanism of Action — DrugBank
• RESUME-1: A Phase III Study of Tolperisone — Taylor & Francis
• Tolperisone for the Treatment of Acute Muscle Spasm: STAR Study — PMC (NIH)