DICLOXMAN-500 — Dicloxacillin 500mg antibiotic, treats bacterial skin infections, wound infections, and abscesses from Staphylococcus bacteria
💊 Active ingredient: Dicloxacillin 500mg — Penicillinase-resistant penicillin
⏱️ How to use: Take 1 capsule every 6 hours (4 times/day) for 7–10 days
🍽️ Conditions: Take 30–60 minutes before meals (empty stomach) for maximum absorption
📦 Pack: 1 strip / 10 capsules, orange-yellow capsules
⚡ Key benefit: Effective against Staph resistant to regular Penicillin — first-line for skin/abscess infections
🌡️ Storage: Below 30°C, away from light and moisture
Shipping
Discreet shipping within Thailand — packaging does not identify the product. Customers can review shipping and return conditions per our store policy. Contact our team for any questions.
Product Description
Penicillinase-resistant penicillin antibiotic DICLOXMAN-500 contains Dicloxacillin 500mg, a beta-lactam antibiotic that inhibits bacterial cell wall synthesis. Unlike regular penicillin, Dicloxacillin 500mg resists penicillinase (beta-lactamase) enzymes, making it the first-line treatment for skin and soft tissue infections caused by Staphylococcus aureus, including cellulitis, abscesses, and wound infections.
📊 Key clinical data
S. aureus accounts for 73–80% of bacterial skin infections worldwide (WHO, 2023)
Dicloxacillin reaches peak plasma levels within 1 hour after oral administration; half-life ~0.7 hours
Bioavailability decreases by ~50% when taken with food — always take on an empty stomach 30–60 min before meals
Clinical cure rate for Staph skin infections with a full Dicloxacillin course: 87–93% (StatPearls, 2024)
⚠️ Warning: Dicloxacillin is an antibiotic. Always complete the full course as directed by your doctor or pharmacist to prevent antibiotic resistance.
Medically reviewed by
ทีมเนื้อหา Intimo Life | Sources: StatPearls, WHO, Drugs.com, Mayo Clinic
Last reviewed: 2026-06-24
About DICLOXMAN-500
What is DICLOXMAN-500?
DICLOXMAN-500 is a penicillinase-resistant penicillin antibiotic containing Dicloxacillin 500mg per capsule in orange-yellow capsules.
Dicloxacillin works by binding to Penicillin-binding proteins (PBPs) on bacterial cell walls, blocking peptidoglycan synthesis — the structural backbone of bacterial cell walls — causing bacterial lysis and death.
Its key advantage is the isoxazolyl side chain, which protects the beta-lactam ring from penicillinase (beta-lactamase) enzymes produced by Staphylococcus aureus. This makes Dicloxacillin 500mg effective against Staph strains resistant to regular Penicillin G and Amoxicillin.
Dicloxacillin is well absorbed orally, suitable for outpatient treatment of mild-to-moderate skin and soft tissue infections (SSTIs) without injections.
What does Dicloxacillin 500mg treat?
Dicloxacillin 500mg treats bacterial infections from susceptible Staphylococcus and Streptococcus species, including:
Skin and soft tissue infections: wound infections, cellulitis, bacterial dermatitis
Dicloxacillin is NOT effective against gram-negative bacteria (e.g. E. coli, Pseudomonas) or MRSA. If MRSA is suspected, consult a doctor for appropriate antibiotic selection.
How to take DICLOXMAN-500 / Dosage
Standard Dicloxacillin 500mg dosage for adults:
Adults and children 40 kg or more: Take Dicloxacillin 500mg every 6 hours (4 times daily) for 7–10 days or as directed
Severe infections: Doctor may increase Dicloxacillin dose to 1,000mg every 6 hours
Children under 40 kg: Consult a doctor for weight-based Dicloxacillin dosing
How to take correctly:
Take 30–60 minutes before meals or 2 hours after eating (empty stomach) — food reduces Dicloxacillin absorption by 50%
Swallow capsules whole; take with a full glass of water
Complete the full 7–10 day course even if symptoms improve — stopping early risks antibiotic resistance
If you miss a dose: take as soon as you remember; if near next dose time, skip — never double dose
Side effects of Dicloxacillin 500mg
Dicloxacillin 500mg is generally well tolerated. Possible side effects include:
Common (mild) side effects:
Nausea, vomiting, stomach upset — 5–10% incidence, especially if not taken on empty stomach
Augmentin (Amoxicillin + Clavulanate) — Broad-spectrum antibiotic covering gram-positive and gram-negative bacteria; Clavulanate blocks beta-lactamase — choose for mixed infections, respiratory, or urinary tract infections
B-Ciprofloxacin (Ciprofloxacin) — Fluoroquinolone with broad gram-negative activity; ideal for UTI and GI infections — not first-line for Staph skin infections
DICLOXMAN-500 (Dicloxacillin 500mg) — Specialized for penicillinase-producing Staphylococcus — choose for confirmed Staph skin, wound, or abscess infection
Bottom line: Choose DICLOXMAN-500 for Staph skin/abscess infections specifically. Choose Augmentin when unsure of the pathogen or for multi-site infections.
Can I take Dicloxacillin with other medicines?
Dicloxacillin 500mg may interact with certain medications:
Warfarin: Dicloxacillin may reduce Warfarin efficacy — monitor INR closely
Hormonal contraceptives: May reduce contraceptive efficacy — use additional protection during Dicloxacillin treatment
Probenecid: Reduces renal Dicloxacillin excretion, increasing drug levels
Antacids: No direct interaction; space 2 hours apart from capsules
Always inform your doctor or pharmacist of all medications, supplements, and herbal products before starting Dicloxacillin 500mg.
Where to buy DICLOXMAN-500?
Where to buy DICLOXMAN-500?
Order DICLOXMAN-500 (Dicloxacillin 500mg antibiotic) online at Intimo Life. We deliver throughout Thailand within 1-3 business days in discreet packaging — product contents are not indicated on the parcel.
⚠️ Disclaimer
The content in this article is for general educational purposes only. It is not intended to replace professional advice, diagnosis, or treatment from a doctor or pharmacist. If you have any questions about symptoms or medication use, always consult a doctor or pharmacist first.
Dicloxacillin 500mg is typically taken for 7–10 consecutive days for skin and soft tissue infections. Severe cases may require up to 14 days. Always complete the full course as prescribed, even if symptoms improve before the course ends.
For adults and children 40 kg or more, take 1 capsule (Dicloxacillin 500mg) every 6 hours — 4 times daily. For severe infections, your doctor may prescribe 2 capsules (1,000mg) per dose.
Always take Dicloxacillin before meals — at least 30–60 minutes before eating, or 2 hours after eating (on an empty stomach). Food reduces Dicloxacillin absorption by up to 50%, which may lower blood drug levels and reduce treatment effectiveness.
Both are penicillin-class antibiotics but differ in spectrum. Amoxicillin covers both gram-positive and gram-negative bacteria but is destroyed by Staph penicillinase. Dicloxacillin is penicillinase-resistant, making it more effective against Staphylococcus aureus strains that resist Amoxicillin. For Staph skin infections and abscesses, Dicloxacillin 500mg is the better choice.
Take the missed Dicloxacillin dose as soon as you remember. If less than 2 hours remain before your next scheduled dose, skip the missed dose. Never double dose to compensate — this increases side effect risk. Maintain consistent 6-hour intervals between doses.
Children weighing 40 kg or more may use adult Dicloxacillin dosing. Children under 40 kg require weight-based dosing (12.5–25 mg/kg/day divided into 4 doses). Always consult a paediatrician or pharmacist before giving Dicloxacillin to children.
Dicloxacillin is FDA Pregnancy Category B — animal studies showed no fetal harm, but adequate human pregnancy studies are lacking. If antibiotic treatment is medically necessary during pregnancy, always consult your obstetrician before taking Dicloxacillin.
Do not stop Dicloxacillin early even if symptoms improve quickly. Residual Staphylococcus bacteria may still be present, and stopping mid-course allows bacteria to develop resistance, leading to more severe relapse. Always complete the full 7–10 day course.
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