Hemorrhoids are common, yet many people avoid seeking treatment out of embarrassment — when relief is simpler than expected. Intimo Life offers ointment and suppository options for targeted relief from pain, itch, and inflammation.
💊 Ointment and suppository for targeted hemorrhoid relief
👨⚕️ Online pharmacist — private, no travel needed
Hemorrhoids are swollen veins in the rectum or anus caused by increased pressure, producing pain, itching, bleeding, or a lump at the anal opening.
📊 Key statistics:
Around 75% of people will experience hemorrhoids at least once in their lifetime
Thailand records over 1 million cases annually; those aged 45–65 are most at risk
Grade 1–2 hemorrhoids can typically be managed with medication alone, without surgery
💊 Available treatments include Doproct Ointment (Hydrocortisone, Zinc Oxide, Benzocaine) for topical anti-inflammatory and local anaesthetic relief, and Doproct Suppository (Lidocaine, Hydrocortisone, Zinc Oxide, Aluminium Acetate) for internal symptom coverage.
⚠️ These medications relieve symptoms but do not permanently cure hemorrhoids. See a doctor if bleeding is heavy or symptoms do not improve.
Hemorrhoids are swollen blood vessels in the rectum and anus caused by increased pressure. Internal hemorrhoids sit inside the rectum — typically painless but may bleed. External hemorrhoids form around the anal opening and cause more pain and itching.
Hemorrhoids are very common during pregnancy due to increased abdominal pressure from the growing baby and progesterone's effect on blood vessel walls, which also worsens constipation.
Self-care includes eating fibre-rich foods, staying hydrated, avoiding prolonged standing or sitting, and warm sitz baths for relief.
Always consult a pharmacist or doctor before using any hemorrhoid medication during pregnancy, especially in the first trimester. Pregnancy-related hemorrhoids usually improve or resolve after delivery as abdominal pressure decreases.
",
"question_en": "Can hemorrhoids heal on their own?",
"answer_en": "
Early-stage hemorrhoids (Grade 1–2) often improve or resolve on their own with lifestyle changes such as increasing fibre intake, staying hydrated, and avoiding straining. However, if you have noticeable symptoms like bleeding, pain, or a prolapsing lump, using medication helps relieve symptoms and speeds up recovery.
",
"question_en": "What is the difference between Doproct Ointment and Doproct Suppository?",
"answer_en": "
Both treat hemorrhoids but suit different locations. Doproct Ointment is applied topically for external hemorrhoids or symptoms near the anal opening. Doproct Suppository is inserted rectally for internal hemorrhoids higher in the rectum. A pharmacist may recommend using both together for broader coverage.
",
"question_en": "How do you use a hemorrhoid suppository?",
"answer_en": "
Wash your hands thoroughly. Lie on your side or bend forward slightly, then gently push the suppository fully into the rectum so it stays in place. It is generally recommended to insert after a bowel movement or at bedtime, once or twice daily. Lying down briefly after insertion helps the medication absorb effectively.
",
"question_en": "Should I see a doctor if I have rectal bleeding from hemorrhoids?",
"answer_en": "
Small amounts of bright red blood on toilet paper or in the bowl are common with hemorrhoids and usually harmless. However, see a doctor if there is heavy bleeding, dark blood mixed with stool, abdominal pain, unexplained weight loss, or if symptoms do not improve after two weeks of medication, as these may indicate a condition requiring further investigation.
",
"question_en": "What is the difference between hemorrhoids and anal skin tags?",
"answer_en": "
Hemorrhoids and anal skin tags are different conditions despite appearing similar. Hemorrhoids are swollen blood vessels that typically bleed and feel soft. Anal skin tags are small pieces of excess skin around the anal opening — painless, non-bleeding, and non-vascular. Treatment differs, so a doctor's diagnosis is recommended.
",
"question_en": "Can hemorrhoids be prevented?",
"answer_en": "
Hemorrhoids can be prevented to a significant extent. The most effective approach is preventing constipation — eat a high-fibre diet with plenty of vegetables and fruit, drink enough water, exercise regularly, and avoid sitting on the toilet for prolonged periods. For those who have had hemorrhoids before, these habits also help reduce the chance of recurrence.
",
"question_en": "What should I do if medication is not working?",
"answer_en": "
If you have used topical medication or suppositories consistently for 1–2 weeks without improvement, or if symptoms are worsening, consult a doctor. Your hemorrhoids may be at a stage requiring a procedural treatment such as rubber band ligation, sclerotherapy, or surgery, or there may be another underlying condition worth investigating.
",
"question_en": "Can hemorrhoids come back after treatment?",
"answer_en": "
Yes, especially if the underlying risk factors remain — such as a low-fibre diet, chronic constipation, or prolonged sitting. Medication relieves symptoms and reduces inflammation during an episode, but does not address root causes. Maintaining good lifestyle habits long-term is the most important factor in preventing recurrence.
Allergic rhinitis (hay fever) occurs when the immune system overreacts to airborne allergens such as pollen, dust mites, or pet dander — triggering histamine release that causes sneezing, nasal discharge, and itchy eyes. Alerest 10 mg contains Cetirizine Dihydrochloride, a selective second-generation H1-receptor antagonist. It competitively blocks peripheral H1 receptors with high selectivity, has limited penetration of the blood-brain barrier, and provides effective allergy relief with significantly less sedation than first-generation antihistamines.
📊 Key clinical data
An environmental exposure unit (EEU) challenge trial showed Cetirizine reduced total symptom complex scores by 36.7% vs 12.0% for placebo — with onset of action within 1 hour, significantly faster than loratadine (onset at 3 hours)
A quality-of-life study (n = 865) found Cetirizine reduced overall symptom severity by 28.9% vs 12.7% placebo, with significant improvements in sleep quality, work productivity, and emotional wellbeing
Single daily dose provides 24-hour coverage — suitable from age 2 and above
🏭 Manufactured by RX Manufacturing Co., Ltd. Registered with Thai FDA under registration number 1A 21/48(NG).
⚠️ Do not drive or operate machinery if drowsiness occurs. Do not consume alcohol while taking this medication.
Medically reviewed by
ทีมเนื้อหา Intimo Life | แหล่งข้อมูล: NCBI StatPearls, J Allergy Clin Immunol 1998, Thai FDA
Last reviewed: 2026-02-19
About Alerest (Cetirizine)
What is Alerest? How Cetirizine Works
Alerest 10 mg is a second-generation H1-receptor antagonist containing Cetirizine Dihydrochloride 10 mg as its active ingredient (ATC: R06AE07). It is manufactured by RX Manufacturing Co., Ltd. and registered with the Thai FDA under registration number 1A 21/48(NG).
Mechanism of Action
Selective peripheral H1-receptor antagonism: Cetirizine competitively and selectively binds to peripheral H1 receptors, preventing histamine from exerting its effects — blocking sneezing, runny nose, itching, and hives at their source.
Limited blood-brain barrier penetration: Unlike first-generation antihistamines (e.g., chlorpheniramine), Cetirizine crosses into the brain only minimally, resulting in significantly less sedation and cognitive impairment.
No anticholinergic activity: Does not cause dry mouth, urinary retention, or other anticholinergic side effects associated with older antihistamine generations.
Pharmacokinetics: Rapidly absorbed — peak plasma levels at ~1 hour. Duration of action: 24 hours. Excreted primarily in urine unchanged. Dose adjustment required in renal impairment.
What Allergy Conditions Does Alerest Treat?
Alerest (Cetirizine) relieves allergic symptoms across multiple conditions:
1. Allergic Rhinitis / Hay Fever
Both seasonal and perennial types. Effective against:
Sneezing, nasal itching, and runny nose
Itchy, watery, and red eyes
Partial relief of nasal congestion
A quality-of-life study (n = 865) found Cetirizine reduced overall symptom severity by 28.9% vs 12.7% with placebo — with significant improvements in sleep, productivity, and activity impairment scores.
2. Chronic Idiopathic Urticaria (Hives)
Reduces the number, size, and itchiness of hives. Cetirizine is recommended in chronic urticaria management guidelines due to its 24-hour action and good long-term tolerability.
3. Other Allergic Skin Reactions
Relieves itching from contact dermatitis, insect bites, and other histamine-mediated skin reactions.
⚠️ Alerest treats allergy symptoms — it is not a cure. For severe or persistent allergic conditions, consult a doctor for a comprehensive long-term management plan.
How to Take Alerest / Dosage by Age
Recommended Dosage
Adults and children 6 years and older: 10 mg (1 tablet) once daily. For milder symptoms, this may be divided into 5 mg (half tablet) twice daily — morning and evening.
Children aged 2–5 years: 5 mg (half tablet) once daily. May be increased to 5 mg twice daily if required by a doctor.
Renal impairment and elderly patients: Dose reduction is required based on creatinine clearance (GFR). Follow your doctor's specific instructions.
How to take:
Can be taken with or without food — food does not significantly affect absorption
Taking at the same time each day helps maintain consistent blood levels
Drink adequate water with each dose
Missed dose: Take as soon as you remember. If close to your next scheduled dose, skip the missed one — never take a double dose.
Duration of use: Take when symptoms occur, or as directed by a doctor. If symptoms do not improve within 3–5 days, consult a doctor or pharmacist.
Side Effects of Alerest (Cetirizine)
Common Side Effects
Drowsiness (~14%): Can occur even with this second-generation drug — particularly at the 10 mg dose. Avoid driving or operating machinery until you know how the drug affects you personally.
Dry mouth: Occasionally reported. Drinking more water helps.
Headache: Occasionally reported; typically temporary and resolves as the body adjusts.
Nausea and stomach pain: Rarely reported. Taking with food can reduce this.
Fatigue: Occasionally reported, especially in elderly patients.
Serious side effects — stop use and seek medical attention immediately:
Hives, facial swelling, or difficulty breathing (signs of anaphylaxis)
Hepatitis: yellowing of eyes or skin, dark urine
Angioedema: swelling of tongue, lips, or throat
vs. First-generation antihistamines: Cetirizine causes significantly less drowsiness than first-generation antihistamines like chlorpheniramine due to substantially lower blood-brain barrier penetration.
Contraindications / Precautions / Drug Interactions
Contraindications
Known allergy to Cetirizine, Hydroxyzine, or any excipient in the formulation
Children under 2 years: Tablet form not recommended
Special Precautions
Renal impairment: Dose reduction is mandatory — cetirizine is primarily renally excreted and will accumulate without adjustment.
Elderly patients: Increased risk of drowsiness and falls. Start with a lower dose.
Pregnancy: Consult a doctor. Not recommended in the third trimester.
Breastfeeding: Excreted in breast milk — not recommended during breastfeeding.
Hepatic impairment: Use with caution.
Drug and substance interactions:
Alcohol: Potentiates CNS depression — significantly worsens drowsiness. Do not consume alcohol while taking cetirizine.
Benzodiazepines / sleeping pills / opioids: Additive CNS depressant effects. Inform your doctor of all medications.
Some antidepressants (TCAs / certain SSRIs): May enhance sedation. Consult a doctor before use.
Cetirizine vs Other Antihistamines
Understanding the differences between antihistamine options helps you choose the right one:
Cetirizine (Alerest) vs First-Generation — Chlorpheniramine (CPM)
Drowsiness: CPM causes significant sedation (high BBB penetration) — best used at bedtime; Cetirizine is significantly less sedating and suitable for daytime use.
Other side effects: CPM causes dry mouth and urinary retention (anticholinergic effects); Cetirizine has none of these.
Cetirizine (Alerest) vs Loratadine
Speed of onset: Cetirizine works within 1 hour; Loratadine takes 3 hours — 3× slower.
Efficacy: EEU trial: Cetirizine reduced symptoms by 36.7% vs Loratadine 15.4% vs Placebo 12.0%.
Drowsiness: Loratadine causes slightly less drowsiness than Cetirizine — preferred for those especially sensitive to sedation.
Cetirizine (Alerest) vs Fexofenadine
Drowsiness: Fexofenadine causes virtually no sedation — ideal for drivers or those operating machinery throughout the day.
Cost: Cetirizine is generally significantly more affordable than fexofenadine.
Urticaria evidence: Cetirizine has a stronger evidence base for chronic urticaria management.
Usage Tips + Storage
Guidance While Using Alerest
Avoid alcohol: Strongly potentiates drowsiness — do not consume alcohol throughout the course of treatment.
Exercise caution when driving: Test your personal response before driving regularly. Cetirizine can cause drowsiness, especially in the first 1–2 hours after the dose.
Optimal timing: If drowsiness is frequent, switch to taking the dose at bedtime instead.
Renal patients: Always confirm dosing with your doctor before starting and monitor kidney function as scheduled.
Elderly patients: Take extra precautions against falls. Sit and rest before standing up after taking the medication.
Alerest relieves three main allergy types: (1) Allergic rhinitis / hay fever — sneezing, runny nose, itchy eyes and nose, both seasonal and perennial; (2) Chronic idiopathic urticaria (hives); and (3) Other histamine-mediated allergic skin reactions.
Alerest is a second-generation antihistamine designed to cause less sedation than first-generation drugs due to limited blood-brain barrier penetration. However, about 14% of users may still experience drowsiness. Test your personal response before driving or operating machinery. If drowsiness occurs frequently, switch to a bedtime dose.
Cetirizine (Alerest) begins working within 1 hour of taking — significantly faster than loratadine which takes 3 hours. It provides 24 hours of continuous relief per dose, making once-daily dosing convenient and effective.
Adults and children 6 and older: 1 tablet (10 mg) once daily. Children 2–5 years: half tablet (5 mg) once daily. Can be taken before, with, or after food — food does not significantly affect absorption.
It depends on the condition. For seasonal or situational allergies, take as needed when symptoms occur. For chronic urticaria or perennial allergic rhinitis, a doctor may recommend daily continuous use for symptom control. Follow your doctor's or pharmacist's specific instructions.
No. Alcohol significantly potentiates the CNS depressant effects of Cetirizine — substantially worsening drowsiness, dizziness, and impaired judgment, and increasing the risk of accidents and injury. Avoid alcohol throughout the course of treatment.
Yes, from age 2 and above with age-appropriate dosing: children 2–5 years: half tablet (5 mg) once daily; children 6 and older: 1 tablet (10 mg) once daily. The tablet form is not recommended for children under 2. Consult a doctor or pharmacist before use in young children.
Pregnant women should always consult a doctor first. Not recommended in the third trimester. Breastfeeding women are advised not to use it, as cetirizine is excreted in breast milk and may cause drowsiness in the infant.
Yes, but dose reduction is required, as cetirizine is primarily renally excreted. In renal impairment, drug accumulation increases side effect risk. Patients with end-stage renal disease on dialysis must not use cetirizine. Consult a doctor for appropriate dose adjustment.
Cetirizine (Alerest) is a second-generation drug with several key advantages: (1) Significantly less drowsiness due to minimal BBB penetration; (2) 24-hour duration vs 4–6 hours for chlorpheniramine; (3) No anticholinergic effects — no dry mouth or urinary retention; (4) More suitable for daytime use and working adults.
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